Osteopetrorickets due to Snx10 Deficiency in Mice Results from Both Failed Osteoclast Activity and Loss of Gastric Acid-Dependent Calcium Absorption

Mutations in sorting nexin 10 (Snx10) have recently been found to account for roughly 4% of all human malignant osteopetrosis, some of them fatal. To study the disease pathogenesis, we investigated the expression of Snx10 and created mouse models in which Snx10 was knocked down globally or knocked o...

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Detalles Bibliográficos
Autores principales: Ye, Liang, Morse, Leslie R., Zhang, Li, Sasaki, Hajime, Mills, Jason C., Odgren, Paul R., Sibbel, Greg, Stanley, James R. L., Wong, Gee, Zamarioli, Ariane, Battaglino, Ricardo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374855/
https://www.ncbi.nlm.nih.gov/pubmed/25811986
http://dx.doi.org/10.1371/journal.pgen.1005057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374855/
https://www.ncbi.nlm.nih.gov/pubmed/25811986
http://dx.doi.org/10.1371/journal.pgen.1005057

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