Lack of Major Genome Instability in Tumors of p53 Null Rats

Tumorigenesis is often associated with loss of tumor suppressor genes (such as TP53), genomic instability and telomere lengthening. Previously, we generated and characterized a rat p53 knockout model in which the homozygous rats predominantly develop hemangiosarcomas whereas the heterozygous rats ma...

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Detalles Bibliográficos
Autores principales: Hermsen, Roel, Toonen, Pim, Kuijk, Ewart, Youssef, Sameh A., Kuiper, Raoul, van Heesch, Sebastiaan, de Bruin, Alain, Cuppen, Edwin, Simonis, Marieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374866/
https://www.ncbi.nlm.nih.gov/pubmed/25811670
http://dx.doi.org/10.1371/journal.pone.0122066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374866/
https://www.ncbi.nlm.nih.gov/pubmed/25811670
http://dx.doi.org/10.1371/journal.pone.0122066

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