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Antithrombin III Deficiency in Indian Patients with Deep Vein Thrombosis: Identification of First India Based AT Variants Including a Novel Point Mutation (T280A) that Leads to Aggregation
Antithrombin III (AT) is the main inhibitor of blood coagulation proteases like thrombin and factor Xa. In this study we report the identification and characterization of several variants of AT for the first time in Indian population. We screened 1950 deep vein thrombosis (DVT) patients for AT activ...
Autores principales: | Bhakuni, Teena, Sharma, Amit, Rashid, Qudsia, Kapil, Charu, Saxena, Renu, Mahapatra, Manoranjan, Jairajpuri, Mohamad Aman |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374914/ https://www.ncbi.nlm.nih.gov/pubmed/25811371 http://dx.doi.org/10.1371/journal.pone.0121889 |
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