Evidence for a Direct Effect of the NAD(+) Precursor Acipimox on Muscle Mitochondrial Function in Humans

Recent preclinical studies showed the potential of nicotinamide adenine dinucleotide (NAD(+)) precursors to increase oxidative phosphorylation and improve metabolic health, but human data are lacking. We hypothesize that the nicotinic acid derivative acipimox, an NAD(+) precursor, would directly aff...

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Detalles Bibliográficos
Autores principales: van de Weijer, Tineke, Phielix, Esther, Bilet, Lena, Williams, Evan G., Ropelle, Eduardo R., Bierwagen, Alessandra, Livingstone, Roshan, Nowotny, Peter, Sparks, Lauren M., Paglialunga, Sabina, Szendroedi, Julia, Havekes, Bas, Moullan, Norman, Pirinen, Eija, Hwang, Jong-Hee, Schrauwen-Hinderling, Vera B., Hesselink, Matthijs K.C., Auwerx, Johan, Roden, Michael, Schrauwen, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375076/
https://www.ncbi.nlm.nih.gov/pubmed/25352640
http://dx.doi.org/10.2337/db14-0667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375076/
https://www.ncbi.nlm.nih.gov/pubmed/25352640
http://dx.doi.org/10.2337/db14-0667

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