Perilipin 5 Regulates Islet Lipid Metabolism and Insulin Secretion in a cAMP-Dependent Manner: Implication of Its Role in the Postprandial Insulin Secretion

Elevation of circulating fatty acids (FA) during fasting supports postprandial (PP) insulin secretion that is critical for glucose homeostasis and is impaired in diabetes. We tested our hypothesis that lipid droplet (LD) protein perilipin 5 (PLIN5) in β-cells aids PP insulin secretion by regulating...

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Detalles Bibliográficos
Autores principales: Trevino, Michelle B., Machida, Yui, Hallinger, Daniel R., Garcia, Eden, Christensen, Aaron, Dutta, Sucharita, Peake, David A., Ikeda, Yasuhiro, Imai, Yumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375085/
https://www.ncbi.nlm.nih.gov/pubmed/25392244
http://dx.doi.org/10.2337/db14-0559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375085/
https://www.ncbi.nlm.nih.gov/pubmed/25392244
http://dx.doi.org/10.2337/db14-0559

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