Cargando…

A tale of a tail: Structural insights into the conformational properties of the polyglutamine protein ataxin-3

Ataxin-3 is the protein responsible for the neurodegenerative polyglutamine disease Spinocerebellar ataxia type 3. Full structural characterisation of ataxin-3 is required to aid in understanding the mechanism of disease. Despite extensive study, little is known about the conformational properties o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scarff, Charlotte A., Sicorello, Alessandro, Tomé, Ricardo J.L., Macedo-Ribeiro, Sandra, Ashcroft, Alison E., Radford, Sheena E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375668/ https://www.ncbi.nlm.nih.gov/pubmed/25844046 http://dx.doi.org/10.1016/j.ijms.2012.08.032

Ejemplares similares

Examination of Ataxin-3 (atx-3) Aggregation by Structural Mass Spectrometry Techniques: A Rationale for Expedited Aggregation upon Polyglutamine (polyQ) Expansion
por: Scarff, Charlotte A., et al.
Publicado: (2015)

Identification of a novel site of interaction between ataxin-3 and the amyloid aggregation inhibitor polyglutamine binding peptide 1
por: Knight, Patrick D, et al.
Publicado: (2017)

Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1
por: Ni, Chun-Lun, et al.
Publicado: (2016)

Insights into the role of the beta-2 microglobulin D-strand in amyloid propensity revealed by mass spectrometry
por: Leney, Aneika C., et al.
Publicado: (2014)

Polyglutamine Expansion Accelerates the Dynamics of Ataxin-1 and Does Not Result in Aggregate Formation
por: Krol, Hilde A., et al.
Publicado: (2008)

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
por: Elden, Andrew C., et al.
Publicado: (2010)

Autophagy mediates SUMO-induced degradation of a polyglutamine protein ataxin-3
por: Hwang, Soo Pyung, et al.
Publicado: (2017)

Removal of the Polyglutamine Repeat of Ataxin-3 by Redirecting pre-mRNA Processing
por: McIntosh, Craig S., et al.
Publicado: (2019)

PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins
por: Janer, Alexandre, et al.
Publicado: (2006)

Large-Scale Screen for Modifiers of Ataxin-3-Derived Polyglutamine-Induced Toxicity in Drosophila
por: Voßfeldt, Hannes, et al.
Publicado: (2012)

The Relationship between Aggregation and Toxicity of Polyglutamine-Containing Ataxin-3 in the Intracellular Environment of Escherichia coli
por: Invernizzi, Gaetano, et al.
Publicado: (2012)

A Major Role for Side-Chain Polyglutamine Hydrogen Bonding in Irreversible Ataxin-3 Aggregation
por: Natalello, Antonino, et al.
Publicado: (2011)

p62/Sequestosome 1 Regulates Aggresome Formation of Pathogenic Ataxin-3 with Expanded Polyglutamine
por: Zhou, Liang, et al.
Publicado: (2014)

Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3
por: Koike, Yuka, et al.
Publicado: (2021)

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1
por: Parfitt, David A., et al.
Publicado: (2009)

The role of conformational flexibility in β(2)-microglobulin amyloid fibril formation at neutral pH
por: Hodkinson, John P, et al.
Publicado: (2012)

Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1
por: Lee, Won-Seok, et al.
Publicado: (2022)

Conformational Behavior and Aggregation of Ataxin-3 in SDS
por: Saunders, Helen M., et al.
Publicado: (2013)

Splice Isoforms of the Polyglutamine Disease Protein Ataxin-3 Exhibit Similar Enzymatic yet Different Aggregation Properties
por: Harris, Ginny Marie, et al.
Publicado: (2010)

Nucleocytoplasmic Shuttling Activity of Ataxin-3
por: Macedo-Ribeiro, Sandra, et al.
Publicado: (2009)

Tales of Tails
por: Essex, Christopher, et al.
Publicado: (2023)

Model Organisms Reveal Insight into Human Neurodegenerative Disease: Ataxin-2 Intermediate-Length Polyglutamine Expansions Are a Risk Factor for ALS
por: Bonini, Nancy M., et al.
Publicado: (2011)

Characterization of the Conformational Fluctuations in the Josephin Domain of Ataxin-3
por: Sanfelice, Domenico, et al.
Publicado: (2014)

The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris
por: Bonanomi, Marcella, et al.
Publicado: (2017)

Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation
por: Johnson, Sean L, et al.
Publicado: (2020)

HDX-ESI-MS Reveals Enhanced Conformational Dynamics of the Amyloidogenic Protein β(2)-Microglobulin upon Release from the MHC-1
por: Hodkinson, John P., et al.
Publicado: (2009)

Tales of tails in transporters
por: Mikros, Emmanuel, et al.
Publicado: (2019)

Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: Implication in a loss-of-function pathology
por: Yang, Hui, et al.
Publicado: (2014)

Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD
por: Ding, Dongxue, et al.
Publicado: (2020)

Ataxin-3 Plays a Role in Mouse Myogenic Differentiation through Regulation of Integrin Subunit Levels
por: Costa, Maria do Carmo, et al.
Publicado: (2010)

Monitoring Copopulated Conformational States During Protein Folding Events Using Electrospray Ionization-Ion Mobility Spectrometry-Mass Spectrometry
por: Smith, David P., et al.
Publicado: (2007)

Publisher Correction: The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris
por: Bonanomi, Marcella, et al.
Publicado: (2018)

A tale of (disordered) tail
por: Roychowdhury, Sumangal, et al.
Publicado: (2023)

Cytoplasmic Ubiquitin-Specific Protease 19 (USP19) Modulates Aggregation of Polyglutamine-Expanded Ataxin-3 and Huntingtin through the HSP90 Chaperone
por: He, Wen-Tian, et al.
Publicado: (2016)

Conserved Pbp1/Ataxin-2 regulates retrotransposon activity and connects polyglutamine expansion-driven protein aggregation to lifespan-controlling rDNA repeats
por: Ostrowski, Lauren A., et al.
Publicado: (2018)

“A tale of tail”: A case of lizard tail abuse
por: Das, Soumitra, et al.
Publicado: (2020)

A Tale of the Tail : A Comprehensive Understanding of the “Human Tail”
por: Tojima, Sayaka
Publicado: (2021)

Designing disorder: Tales of the unexpected tails
por: Minde, David P, et al.
Publicado: (2013)

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
por: Daldin, Manuel, et al.
Publicado: (2017)

A Robust Assay to Monitor Ataxin-3 Amyloid Fibril Assembly
por: Figueiredo, Francisco, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9talg5a84iu972fjre8fih2ge8