Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics

Nonsense-mediated mRNA decay (NMD) limits the production of aberrant mRNAs containing a premature termination codon and also controls the levels of endogenous transcripts. Here we show that when human cells are treated with clinically used chemotherapeutic compounds, NMD activity declines partly as...

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Detalles Bibliográficos
Autores principales: Popp, Maximilian W., Maquat, Lynne E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375787/
https://www.ncbi.nlm.nih.gov/pubmed/25808464
http://dx.doi.org/10.1038/ncomms7632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375787/
https://www.ncbi.nlm.nih.gov/pubmed/25808464
http://dx.doi.org/10.1038/ncomms7632

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