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Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics
Nonsense-mediated mRNA decay (NMD) limits the production of aberrant mRNAs containing a premature termination codon and also controls the levels of endogenous transcripts. Here we show that when human cells are treated with clinically used chemotherapeutic compounds, NMD activity declines partly as...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375787/ https://www.ncbi.nlm.nih.gov/pubmed/25808464 http://dx.doi.org/10.1038/ncomms7632 |