Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

Soluble karyopherins of the importin-β (impβ) family use RanGTP to transport cargos directionally through the nuclear pore complex (NPC). Whether impβ or RanGTP regulate the permeability of the NPC itself has been unknown. In this study, we identify a stable pool of impβ at the NPC. A subpopulation...

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Detalles Bibliográficos
Autores principales: Lowe, Alan R, Tang, Jeffrey H, Yassif, Jaime, Graf, Michael, Huang, William YC, Groves, Jay T, Weis, Karsten, Liphardt, Jan T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375889/
https://www.ncbi.nlm.nih.gov/pubmed/25748139
http://dx.doi.org/10.7554/eLife.04052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375889/
https://www.ncbi.nlm.nih.gov/pubmed/25748139
http://dx.doi.org/10.7554/eLife.04052

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