Disease-specific monoclonal antibodies targeting glutamate decarboxylase impair GABAergic neurotransmission and affect motor learning and behavioral functions

Autoantibodies to the smaller isoform of glutamate decarboxylase (GAD) can be found in patients with type 1 diabetes and a number of neurological disorders, including stiff-person syndrome, cerebellar ataxia and limbic encephalitis. The detection of disease-specific autoantibody epitopes led to the...

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Detalles Bibliográficos
Autores principales: Manto, Mario, Honnorat, Jérôme, Hampe, Christiane S., Guerra-Narbona, Rafael, López-Ramos, Juan Carlos, Delgado-García, José María, Saitow, Fumihito, Suzuki, Hidenori, Yanagawa, Yuchio, Mizusawa, Hidehiro, Mitoma, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375997/
https://www.ncbi.nlm.nih.gov/pubmed/25870548
http://dx.doi.org/10.3389/fnbeh.2015.00078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375997/
https://www.ncbi.nlm.nih.gov/pubmed/25870548
http://dx.doi.org/10.3389/fnbeh.2015.00078

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