Notum deacylates Wnts to suppress signalling activity

Signalling by Wnts is finely balanced to ensure normal development and tissue homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a highly conserved secreted feedback antagonist. Notum has been thought to act as a phospholipase, shedding glypicans and associated Wn...

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Detalles Bibliográficos
Autores principales: Kakugawa, Satoshi, Langton, Paul F., Zebisch, Matthias, Howell, Steve, Chang, Tao-Hsin, Liu, Yan, Feizi, Ten, Bineva, Ganka, O’Reilly, Nicola, Snijders, Ambrosius P., Jones, E. Yvonne, Vincent, Jean-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376489/
https://www.ncbi.nlm.nih.gov/pubmed/25731175
http://dx.doi.org/10.1038/nature14259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376489/
https://www.ncbi.nlm.nih.gov/pubmed/25731175
http://dx.doi.org/10.1038/nature14259

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