Phosphodiesterase 9A Controls Nitric-oxide Independent cGMP and Hypertrophic Heart Disease

Cyclic guanosine monophosphate (cGMP) is a second messenger molecule that transduces nitric oxide (NO) and natriuretic peptide (NP) coupled signaling, stimulating phosphorylation changes by protein kinase G (PKG). Enhancing cGMP synthesis or blocking its degradation by phosphodiesterase type 5A (PDE...

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Detalles Bibliográficos
Autores principales: Lee, Dong I., Zhu, Guangshuo, Sasaki, Takashi, Cho, Gun-Sik, Hamdani, Nazha, Holewinski, Ronald, Jo, Su-Hyun, Danner, Thomas, Zhang, Manling, Rainer, Peter P., Bedja, Djahida, Kirk, Jonathan A., Ranek, Mark J., Dostmann, Wolfgang R., Kwon, Chulan, Margulies, Kenneth B., Van Eyk, Jennifer E., Paulus, Walter J., Takimoto, Eiki, Kass, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376609/
https://www.ncbi.nlm.nih.gov/pubmed/25799991
http://dx.doi.org/10.1038/nature14332

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376609/
https://www.ncbi.nlm.nih.gov/pubmed/25799991
http://dx.doi.org/10.1038/nature14332

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