STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel

The ER-resident regulatory protein STIM1 triggers store-operated Ca(2+) entry by direct interaction with the plasma membrane Ca(2+) channel ORAI1. The mechanism of channel gating remains undefined. Here we establish that STIM1 gates the purified recombinant ORAI1 channel in vitro, and use Tb(3+) lum...

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Detalles Bibliográficos
Autores principales: Gudlur, Aparna, Quintana, Ariel, Zhou, Yubin, Hirve, Nupura, Mahapatra, Sahasransu, Hogan, Patrick G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376667/
https://www.ncbi.nlm.nih.gov/pubmed/25296861
http://dx.doi.org/10.1038/ncomms6164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376667/
https://www.ncbi.nlm.nih.gov/pubmed/25296861
http://dx.doi.org/10.1038/ncomms6164

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