An S188V Mutation Alters Substrate Specificity of Non-Stereospecific α-Haloalkanoic Acid Dehalogenase E (DehE)

The non-stereospecific α-haloalkanoic acid dehalogenase E (DehE) degrades many halogenated compounds but is ineffective against β-halogenated compounds such as 3-chloropropionic acid (3CP). Using molecular dynamics (MD) simulations and site-directed mutagenesis we show here that introducing the muta...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdul Hamid, Azzmer Azzar, Tengku Abdul Hamid, Tengku Haziyamin, Abdul Wahab, Roswanira, Omar, Mohd. Shahir Shamsir, Huyop, Fahrul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376737/
https://www.ncbi.nlm.nih.gov/pubmed/25816329
http://dx.doi.org/10.1371/journal.pone.0121687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4376737/
https://www.ncbi.nlm.nih.gov/pubmed/25816329
http://dx.doi.org/10.1371/journal.pone.0121687

Ejemplares similares