Coexpression of gene Oct4 and Nanog initiates stem cell characteristics in hepatocellular carcinoma and promotes epithelial-mesenchymal transition through activation of Stat3/Snail signaling

BACKGROUND: Oct4 and Nanog are key regulatory genes that maintain the pluripotency and self-renewal properties of embryonic stem cells. We previously reported that the two stemness markers were tightly associated with cancer progression and poor outcomes of hepatocellular carcinoma. In this study, w...

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Detalles Bibliográficos
Autores principales: Yin, Xin, Zhang, Bo-Heng, Zheng, Su-Su, Gao, Dong-Mei, Qiu, Shuang-Jian, Wu, Wei-Zhong, Ren, Zheng-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377043/
https://www.ncbi.nlm.nih.gov/pubmed/25879771
http://dx.doi.org/10.1186/s13045-015-0119-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377043/
https://www.ncbi.nlm.nih.gov/pubmed/25879771
http://dx.doi.org/10.1186/s13045-015-0119-3

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