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A New Class of Cancer-Associated PTEN Mutations Defined by Membrane Translocation Defects
Phosphatase and tensin homolog (PTEN), which negatively regulates tumorigenic PIP3 signaling, is a commonly mutated tumor suppressor. The majority of cancer-associated PTEN mutations block its essential PIP3 phosphatase activity. However, there is a group of clinically identified PTEN mutations that...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377315/ https://www.ncbi.nlm.nih.gov/pubmed/25263454 http://dx.doi.org/10.1038/onc.2014.293 |