Esculetin Downregulates the Expression of AML1-ETO and C-Kit in Kasumi-1 Cell Line by Decreasing Half-Life of mRNA

One of the most frequent genetic aberrations in acute myeloid leukemia (AML) is chromosomal translocation between AML1/RUNX1 on chromosome 21 and ETO gene on chromosome 8 resulting in the expression of chimeric oncogene AML1-ETO. Although patients with t(8;21) translocation have good prognosis, 5-ye...

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Detalles Bibliográficos
Autores principales: Sawney, Sharad, Arora, Rashi, Aggarwal, Kamal K., Saluja, Daman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377501/
https://www.ncbi.nlm.nih.gov/pubmed/25861270
http://dx.doi.org/10.1155/2015/781473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377501/
https://www.ncbi.nlm.nih.gov/pubmed/25861270
http://dx.doi.org/10.1155/2015/781473

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