Pleiotropic effects of extended blockade of CSF1R signaling in adult mice

We investigated the role of CSF1R signaling in adult mice using prolonged treatment with anti-CSF1R antibody. Mutation of the CSF1 gene in the op/op mouse produces numerous developmental abnormalities. Mutation of the CSF1R has an even more penetrant phenotype, including perinatal lethality, because...

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Detalles Bibliográficos
Autores principales: Sauter, Kristin A., Pridans, Clare, Sehgal, Anuj, Tsai, Yi Ting, Bradford, Barry M., Raza, Sobia, Moffat, Lindsey, Gow, Deborah J., Beard, Philippa M., Mabbott, Neil A., Smith, Lee B., Hume, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Leukocyte Biology 2014
Materias:
Receptors, Signal Transduction, & Genes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378363/
https://www.ncbi.nlm.nih.gov/pubmed/24652541
http://dx.doi.org/10.1189/jlb.2A0114-006R

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378363/
https://www.ncbi.nlm.nih.gov/pubmed/24652541
http://dx.doi.org/10.1189/jlb.2A0114-006R

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