Cargando…

Pleiotropic effects of extended blockade of CSF1R signaling in adult mice

We investigated the role of CSF1R signaling in adult mice using prolonged treatment with anti-CSF1R antibody. Mutation of the CSF1 gene in the op/op mouse produces numerous developmental abnormalities. Mutation of the CSF1R has an even more penetrant phenotype, including perinatal lethality, because...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sauter, Kristin A., Pridans, Clare, Sehgal, Anuj, Tsai, Yi Ting, Bradford, Barry M., Raza, Sobia, Moffat, Lindsey, Gow, Deborah J., Beard, Philippa M., Mabbott, Neil A., Smith, Lee B., Hume, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Leukocyte Biology 2014
Materias:	Receptors, Signal Transduction, & Genes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378363/ https://www.ncbi.nlm.nih.gov/pubmed/24652541 http://dx.doi.org/10.1189/jlb.2A0114-006R

Ejemplares similares

A degradatory fate for CCR4 suggests a primary role in Th2 inflammation
por: Anderson, Caroline A., et al.
Publicado: (2020)

Phosphatase inhibitor PPP1R11 modulates resistance of human T cells toward Treg‐mediated suppression of cytokine expression
por: Joshi, Rubin N., et al.
Publicado: (2019)

CD200R1L is a functional evolutionary conserved activating receptor in human neutrophils
por: Pascoal Ramos, M. Inês, et al.
Publicado: (2021)

Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity
por: Glinka, Yelena, et al.
Publicado: (2008)

An essential role for IFN-β in the induction of IFN-stimulated gene expression by LPS in macrophages
por: Sheikh, Faruk, et al.
Publicado: (2014)

Decidual natural killer cell receptor expression is altered in pregnancies with impaired vascular remodeling and a higher risk of pre-eclampsia
por: Wallace, Alison E., et al.
Publicado: (2015)

CCR5 susceptibility to ligand-mediated down-modulation differs between human T lymphocytes and myeloid cells
por: Fox, James M., et al.
Publicado: (2015)

Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte–derived macrophages: the importance of HIV-1 envelope V1V2 region
por: Jobe, Ousman, et al.
Publicado: (2016)

The θ‐defensin retrocyclin 101 inhibits TLR4‐ and TLR2‐dependent signaling and protects mice against influenza infection
por: Prantner, Daniel, et al.
Publicado: (2017)

WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts
por: Malinova, Dessislava, et al.
Publicado: (2016)

EPH receptor B2 stimulates human monocyte adhesion and migration independently of its EphrinB ligands
por: Vreeken, Dianne, et al.
Publicado: (2020)

RNF144B inhibits LPS‐induced inflammatory responses via binding TBK1
por: Zhang, Zhen, et al.
Publicado: (2019)

Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils
por: Frei, Robert, et al.
Publicado: (2020)

Role of endocytosis and trans‐endocytosis in ICOS costimulator‐induced downmodulation of the ICOS Ligand
por: Aragoneses‐Fenoll, Laura, et al.
Publicado: (2021)

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2 complex
por: Lind, Simon, et al.
Publicado: (2020)

Differential expression and regulation of MS4A family members in myeloid cells in physiological and pathological conditions
por: Silva‐Gomes, Rita, et al.
Publicado: (2021)

Agonist-induced internalization and downregulation of gonadotropin-releasing hormone receptors
por: Finch, Ann R., et al.
Publicado: (2009)

Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry
por: Pagano, Mario, et al.
Publicado: (2009)

Hyperosmolarity regulates SOX9 mRNA posttranscriptionally in human articular chondrocytes
por: Tew, Simon R., et al.
Publicado: (2009)

Spatially Restricted G Protein-coupled Receptor Activity via Divergent Endocytic Compartments
por: Jean-Alphonse, Frederic, et al.
Publicado: (2014)

The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche
por: Sehgal, Anuj, et al.
Publicado: (2018)

Mechanisms Controlling Glucose-Induced GLP-1 Secretion in Human Small Intestine
por: Sun, Emily W., et al.
Publicado: (2017)

Glucose-Induced Nuclear Shuttling of ChREBP Is Mediated by Sorcin and Ca(2+) Ions in Pancreatic β-Cells
por: Noordeen, Nafeesa A., et al.
Publicado: (2012)

Syk-dependent Phosphorylation of CLEC-2: A NOVEL MECHANISM OF HEM-IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF SIGNALING
por: Séverin, Sonia, et al.
Publicado: (2011)

Critical Role for an Acidic Amino Acid Region in Platelet Signaling by the HemITAM (Hemi-immunoreceptor Tyrosine-based Activation Motif) Containing Receptor CLEC-2 (C-type Lectin Receptor-2)
por: Hughes, Craig E., et al.
Publicado: (2013)

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors
por: Weston, Cathryn, et al.
Publicado: (2016)

Focal Adhesion Remodeling Is Crucial for Glucose-Stimulated Insulin Secretion and Involves Activation of Focal Adhesion Kinase and Paxillin
por: Rondas, Dieter, et al.
Publicado: (2011)

The Extracellular Matrix Protein MAGP1 Supports Thermogenesis and Protects Against Obesity and Diabetes Through Regulation of TGF-β
por: Craft, Clarissa S., et al.
Publicado: (2014)

Identification of Human P2X1 Receptor-interacting Proteins Reveals a Role of the Cytoskeleton in Receptor Regulation
por: Lalo, Ulyana, et al.
Publicado: (2011)

Class II Histone Deacetylases Downregulate GLUT4 Transcription in Response to Increased cAMP Signaling in Cultured Adipocytes and Fasting Mice
por: Weems, Juston C., et al.
Publicado: (2012)

Elevated Carbon Dioxide Blunts Mammalian cAMP Signaling Dependent on Inositol 1,4,5-Triphosphate Receptor-mediated Ca(2+) Release
por: Cook, Zara C., et al.
Publicado: (2012)

Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties
por: Watkins, Harriet A., et al.
Publicado: (2016)

Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice
por: Ropelle, Eduardo R., et al.
Publicado: (2013)

Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress
por: Senokuchi, Takafumi, et al.
Publicado: (2008)

Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
por: Soares, Marc A., et al.
Publicado: (2016)

Examining Crosstalk among Transforming Growth Factor β, Bone Morphogenetic Protein, and Wnt Pathways
por: Coster, Adam D., et al.
Publicado: (2017)

Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding
por: Telezhkin, Vsevolod, et al.
Publicado: (2012)

Temporal Profiling of Orexin Receptor-Arrestin-Ubiquitin Complexes Reveals Differences between Receptor Subtypes
por: Dalrymple, Matthew B., et al.
Publicado: (2011)

Nuclear Receptors HNF4α and LRH-1 Cooperate in Regulating Cyp7a1 in Vivo
por: Kir, Serkan, et al.
Publicado: (2012)

A ubiquitin-like domain controls protein kinase D dimerization and activation by trans-autophosphorylation
por: Elsner, Daniel J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_576muqp0t7im2l2p6appnthisl