Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs

The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that...

Descripción completa

Detalles Bibliográficos
Autores principales: de Wit, Emmie, Marzi, Andrea, Bushmaker, Trenton, Brining, Doug, Scott, Dana, Richt, Juergen A., Geisbert, Thomas W., Feldmann, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2015
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378486/
https://www.ncbi.nlm.nih.gov/pubmed/25811738
http://dx.doi.org/10.3201/eid2104.142012
Descripción
Sumario:The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.

Ejemplares similares