Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs

The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that...

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Detalles Bibliográficos
Autores principales: de Wit, Emmie, Marzi, Andrea, Bushmaker, Trenton, Brining, Doug, Scott, Dana, Richt, Juergen A., Geisbert, Thomas W., Feldmann, Heinz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2015
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378486/
https://www.ncbi.nlm.nih.gov/pubmed/25811738
http://dx.doi.org/10.3201/eid2104.142012
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author de Wit, Emmie
Marzi, Andrea
Bushmaker, Trenton
Brining, Doug
Scott, Dana
Richt, Juergen A.
Geisbert, Thomas W.
Feldmann, Heinz
author_facet de Wit, Emmie
Marzi, Andrea
Bushmaker, Trenton
Brining, Doug
Scott, Dana
Richt, Juergen A.
Geisbert, Thomas W.
Feldmann, Heinz
author_sort de Wit, Emmie
collection PubMed
description The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs.
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spelling pubmed-43784862015-04-01 Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs de Wit, Emmie Marzi, Andrea Bushmaker, Trenton Brining, Doug Scott, Dana Richt, Juergen A. Geisbert, Thomas W. Feldmann, Heinz Emerg Infect Dis Dispatch The ongoing Ebola outbreak in West Africa has resulted in fast-track development of vaccine candidates. We tested a vesicular stomatitis virus vector expressing Ebola virus glycoprotein for safety in pigs. Inoculation did not cause disease and vaccine virus shedding was minimal, which indicated that the vaccine virus does not pose a risk of dissemination in pigs. Centers for Disease Control and Prevention 2015-04 /pmc/articles/PMC4378486/ /pubmed/25811738 http://dx.doi.org/10.3201/eid2104.142012 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Dispatch
de Wit, Emmie
Marzi, Andrea
Bushmaker, Trenton
Brining, Doug
Scott, Dana
Richt, Juergen A.
Geisbert, Thomas W.
Feldmann, Heinz
Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs
title Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs
title_full Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs
title_fullStr Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs
title_full_unstemmed Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs
title_short Safety of Recombinant VSV–Ebola Virus Vaccine Vector in Pigs
title_sort safety of recombinant vsv–ebola virus vaccine vector in pigs
topic Dispatch
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378486/
https://www.ncbi.nlm.nih.gov/pubmed/25811738
http://dx.doi.org/10.3201/eid2104.142012
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