Cargando…

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

BACKGROUND: Activation of microglia plays a crucial role in immune and inflammatory processes after ischemic stroke. Microglia is reported with two opposing activated phenotypes, namely, classic phenotype (M1) and the alternative phenotype (M2). Inhibiting M1 while stimulating M2 has been suggested...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Jie, Jin, Jia-li, Ge, Hui-ming, Yin, Kai-lin, Chen, Xiang, Han, Li-juan, Chen, Yan, Qian, Lai, Li, Xiao-xi, Xu, Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378556/ https://www.ncbi.nlm.nih.gov/pubmed/25889216 http://dx.doi.org/10.1186/s12974-015-0270-3

Ejemplares similares

Oleoylethanolamide Protects against Acute Ischemic Stroke by Promoting PPARα-Mediated Microglia/Macrophage M2 Polarization
por: Li, Ying, et al.
Publicado: (2023)

Modular Synthesis of Polyphenolic Benzofurans, and Application in the Total Synthesis of Malibatol A and Shoreaphenol
por: Chen, David Y.-K., et al.
Publicado: (2010)

Ultrasound reduces inflammation by modulating M1/M2 polarization of microglia through STAT1/STAT6/PPARγ signaling pathways
por: Hsu, Chin‐Hung, et al.
Publicado: (2023)

M2 microglia promotes neurogenesis and oligodendrogenesis from neural stem/progenitor cells via the PPARγ signaling pathway
por: Yuan, Jichao, et al.
Publicado: (2017)

Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages
por: Tian, Ying, et al.
Publicado: (2019)

Symmetry-based approach to oligostilbenoids: Rapid entry to viniferifuran, shoreaphenol, malibatol A, and diptoindonesin G
por: Jung, Youngeun, et al.
Publicado: (2016)

Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer’s Disease Model
por: Sanjay, et al.
Publicado: (2022)

Adiponectin Ameliorates GMH-Induced Brain Injury by Regulating Microglia M1/M2 Polarization Via AdipoR1/APPL1/AMPK/PPARγ Signaling Pathway in Neonatal Rats
por: Xu, Ningbo, et al.
Publicado: (2022)

Adiponectin Regulates the Polarization and Function of Microglia via PPAR-γ Signaling Under Amyloid β Toxicity
por: Song, Juhyun, et al.
Publicado: (2017)

Microglia Polarization From M1 to M2 in Neurodegenerative Diseases
por: Guo, Shenrui, et al.
Publicado: (2022)

Microglia Exhibit Distinct Heterogeneity Rather than M1/M2 Polarization within the Early Stage of Acute Ischemic Stroke
por: Ma, Hongyu, et al.
Publicado: (2023)

Redox Regulation of PPARγ in Polarized Macrophages
por: Trümper, Verena, et al.
Publicado: (2020)

Sinapic Acid Attenuated Cardiac Remodeling After Myocardial Infarction by Promoting Macrophage M2 Polarization Through the PPARγ Pathway
por: Yang, Mei, et al.
Publicado: (2022)

Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease
por: Luo, Wenjing, et al.
Publicado: (2017)

Modulators of microglia activation and polarization in ischemic stroke
por: Jiang, Cheng-Ting, et al.
Publicado: (2020)

Minocycline selectively inhibits M1 polarization of microglia
por: Kobayashi, K, et al.
Publicado: (2013)

Structural dataset for the PPARγ V290M mutant
por: Puhl, Ana C., et al.
Publicado: (2016)

The TFPI2–PPARγ axis induces M2 polarization and inhibits fibroblast activation to promote recovery from post-myocardial infarction in diabetic mice
por: Guo, Mengqi, et al.
Publicado: (2023)

Propofol ameliorates renal ischemia/reperfusion injury by enhancing macrophage M2 polarization through PPARγ/STAT3 signaling
por: Liu, Zhaohui, et al.
Publicado: (2021)

Acidic Microenvironment Aggravates the Severity of Hepatic Ischemia/Reperfusion Injury by Modulating M1-Polarization Through Regulating PPAR-γ Signal
por: Ding, Wei, et al.
Publicado: (2021)

Effect of testosterone on the expression of PPARγ mRNA in PCOS patients
por: Cao, Jinghe, et al.
Publicado: (2019)

Regulation of PPAR-γ activity in lipid-laden hepatocytes affects macrophage polarization and inflammation in nonalcoholic fatty liver disease
por: Li, Xiao-Yun, et al.
Publicado: (2022)

PPARγ/mTOR Regulates the Synthesis and Release of Prostaglandins in Ovine Trophoblast Cells in Early Pregnancy
por: Hao, Kexing, et al.
Publicado: (2022)

Pioglitazone, a PPAR-γ Activator, Stimulates BK(Ca) but Suppresses IK(M) in Hippocampal Neurons
por: Chen, Tsang-Shan, et al.
Publicado: (2018)

Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization
por: Wang, Guoqing, et al.
Publicado: (2022)

MiR-29a Knockout Aggravates Neurological Damage by Pre-polarizing M1 Microglia in Experimental Rat Models of Acute Stroke
por: Zhao, Fangfang, et al.
Publicado: (2021)

Therapeutic Potential of PPARγ Activation in Stroke
por: Vemuganti, Raghu
Publicado: (2008)

Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization
por: Shu, Nan, et al.
Publicado: (2023)

Low‐dose decitabine promotes M2 macrophage polarization in patients with primary immune thrombocytopenia via enhancing KLF4 binding to PPARγ promoter
por: Shao, Xia, et al.
Publicado: (2023)

Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures
por: Zhang, Bei, et al.
Publicado: (2019)

Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration
por: Zhou, Tian, et al.
Publicado: (2017)

PPAR-γ Mediates Ta-VNS-Induced Angiogenesis and Subsequent Functional Recovery after Experimental Stroke in Rats
por: Li, Jiani, et al.
Publicado: (2020)

The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization
por: Zizzo, Gaetano, et al.
Publicado: (2015)

PPARβ/δ Agonist Alleviates Diabetic Osteoporosis via Regulating M1/M2 Macrophage Polarization
por: Chen, Miao, et al.
Publicado: (2021)

Functional Expression of Choline Transporters in Microglia and Their Regulation of Microglial M1/M2 Polarization
por: Okada, Toshio, et al.
Publicado: (2022)

Corrigendum: MiR-29a Knockout Aggravates Neurological Damage by Pre-polarizing M1 Microglia in Experimental Rat Models of Acute Stroke
por: Zhao, Fangfang, et al.
Publicado: (2021)

Sestrin2 regulates microglia polarization through mTOR-mediated autophagic flux to attenuate inflammation during experimental brain ischemia
por: He, Tingting, et al.
Publicado: (2020)

Nur77 and PPARγ regulate transcription and polarization in distinct subsets of M2-like reparative macrophages during regenerative inflammation
por: Garabuczi, Éva, et al.
Publicado: (2023)

Adenosine A(2A) Receptor in Bone Marrow-Derived Cells Mediated Macrophages M2 Polarization via PPARγ-P65 Pathway in Chronic Hypoperfusion Situation
por: Mou, Ke-Jie, et al.
Publicado: (2022)

Asperosaponin VI inhibits LPS-induced inflammatory response by activating PPAR-γ pathway in primary microglia
por: Zhang, Jinqiang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dmlcatlq9dso01flj7qimv34dt