Properties of Neurons Derived from Induced Pluripotent Stem Cells of Gaucher Disease Type 2 Patient Fibroblasts: Potential Role in Neuropathology

Gaucher disease (GD) is caused by insufficient activity of acid β-glucosidase (GCase) resulting from mutations in GBA1. To understand the pathogenesis of the neuronopathic GD, induced pluripotent stem cells (iPSCs) were generated from fibroblasts isolated from three GD type 2 (GD2) and 2 unaffected...

Descripción completa

Detalles Bibliográficos
Autores principales: Sun, Ying, Florer, Jane, Mayhew, Christopher N., Jia, Zhanfeng, Zhao, Zhiying, Xu, Kui, Ran, Huimin, Liou, Benjamin, Zhang, Wujuan, Setchell, Kenneth D. R., Gu, Jianguo, Grabowski, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378893/
https://www.ncbi.nlm.nih.gov/pubmed/25822147
http://dx.doi.org/10.1371/journal.pone.0118771

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378893/
https://www.ncbi.nlm.nih.gov/pubmed/25822147
http://dx.doi.org/10.1371/journal.pone.0118771

Ejemplares similares