The Effect of Exon 7 Deletion during the Evolution of TRIMCyp Fusion Proteins on Viral Restriction, Cytoplasmic Body Formation and Multimerization

TRIMCyp is a fusion protein consisting of the TRIM5 gene product and retrotransposed Cyclophilin A (CypA). Two primate TRIMCyp fusion proteins with varying anti-HIV-1 activities independently evolved in owl monkeys and Old World monkeys. In addition, Old World monkey TRIMCyps lack exon7, which encod...

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Detalles Bibliográficos
Autores principales: Liu, Feng Liang, Kuang, Yi Qun, Mu, Dan, Zheng, Hong Yi, Zhu, Jia Wu, Zheng, Yong Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378998/
https://www.ncbi.nlm.nih.gov/pubmed/25822622
http://dx.doi.org/10.1371/journal.pone.0121666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378998/
https://www.ncbi.nlm.nih.gov/pubmed/25822622
http://dx.doi.org/10.1371/journal.pone.0121666

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