Genomic DNA Hypomethylation Is Associated with Neural Tube Defects Induced by Methotrexate Inhibition of Folate Metabolism

DNA methylation is thought to be involved in the etiology of neural tube defects (NTDs). However, the exact mechanism between DNA methylation and NTDs remains unclear. Herein, we investigated the change of methylation in mouse model of NTDs associated with folate dysmetabolism by use of ultraperform...

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Detalles Bibliográficos
Autores principales: Wang, Xiuwei, Guan, Zhen, Chen, Yan, Dong, Yanting, Niu, Yuhu, Wang, Jianhua, Zhang, Ting, Niu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379001/
https://www.ncbi.nlm.nih.gov/pubmed/25822193
http://dx.doi.org/10.1371/journal.pone.0121869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379001/
https://www.ncbi.nlm.nih.gov/pubmed/25822193
http://dx.doi.org/10.1371/journal.pone.0121869

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