DJ-1 Knockout Augments Disease Severity and Shortens Survival in a Mouse Model of ALS

Amyotrophic lateral sclerosis (ALS) is a progressive, lethal, neurodegenerative disorder, characterized by the degeneration of motor neurons. Oxidative stress plays a central role in the disease progression, in concert with an enhanced glutamate excitotoxicity and neuroinflammation. DJ-1 mutations,...

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Detalles Bibliográficos
Autores principales: Lev, Nirit, Barhum, Yael, Lotan, Itay, Steiner, Israel, Offen, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379040/
https://www.ncbi.nlm.nih.gov/pubmed/25822630
http://dx.doi.org/10.1371/journal.pone.0117190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379040/
https://www.ncbi.nlm.nih.gov/pubmed/25822630
http://dx.doi.org/10.1371/journal.pone.0117190

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