Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

BACKGROUND: Mitochondrial DNA (mtDNA) copy number decreases in animal and human heart failure (HF), yet its role in cardiomyocytes remains to be elucidated. Thus, we investigated the cardioprotective function of increased mtDNA copy number resulting from the overexpression of human transcription fac...

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Detalles Bibliográficos
Autores principales: Ikeda, Masataka, Ide, Tomomi, Fujino, Takeo, Arai, Shinobu, Saku, Keita, Kakino, Takamori, Tyynismaa, Henna, Yamasaki, Toshihide, Yamada, Ken-ichi, Kang, Dongchon, Suomalainen, Anu, Sunagawa, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379048/
https://www.ncbi.nlm.nih.gov/pubmed/25822152
http://dx.doi.org/10.1371/journal.pone.0119687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379048/
https://www.ncbi.nlm.nih.gov/pubmed/25822152
http://dx.doi.org/10.1371/journal.pone.0119687

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