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A polymorphism in HLA-G modifies statin benefit in asthma

Several reports have shown that statin treatment benefits patients with asthma, however inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress HLA-G expression, and rs1063320, a common SNP in the HLA-G 3’UTR which is a...

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Autores principales: Naidoo, Devesh, Wu, Ann C, Brilliant, Murray H, Denny, Joshua, Ingram, Christie, Kitchner, Terrie E, Linneman, James G, McGeachie, Michael J, Roden, Dan M, Shaffer, Christian M, Shah, Anushi, Weeke, Peter, Weiss, Scott T, Xu, Hua, Medina, Marisa W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379135/
https://www.ncbi.nlm.nih.gov/pubmed/25266681
http://dx.doi.org/10.1038/tpj.2014.55
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author Naidoo, Devesh
Wu, Ann C
Brilliant, Murray H
Denny, Joshua
Ingram, Christie
Kitchner, Terrie E
Linneman, James G
McGeachie, Michael J
Roden, Dan M
Shaffer, Christian M
Shah, Anushi
Weeke, Peter
Weiss, Scott T
Xu, Hua
Medina, Marisa W
author_facet Naidoo, Devesh
Wu, Ann C
Brilliant, Murray H
Denny, Joshua
Ingram, Christie
Kitchner, Terrie E
Linneman, James G
McGeachie, Michael J
Roden, Dan M
Shaffer, Christian M
Shah, Anushi
Weeke, Peter
Weiss, Scott T
Xu, Hua
Medina, Marisa W
author_sort Naidoo, Devesh
collection PubMed
description Several reports have shown that statin treatment benefits patients with asthma, however inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress HLA-G expression, and rs1063320, a common SNP in the HLA-G 3’UTR which is associated with asthma risk, modulates miRNA binding. We report that statins up-regulate mir-148b and 152, and affect HLA-G expression in an rs1063320 dependent fashion. In addition, we found that individuals who carried the G minor allele of rs1063320 had reduced asthma related exacerbations (emergency department visits, hospitalizations or oral steroid use) compared to non-carriers (p=0.03) in statin users ascertained in the Personalized Medicine Research Project at the Marshfield Clinic (n=421). These findings support the hypothesis that rs1063320 modifies the effect of statin benefit in asthma, and thus may contribute to variation in statin efficacy for the management of this disease.
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spelling pubmed-43791352015-12-01 A polymorphism in HLA-G modifies statin benefit in asthma Naidoo, Devesh Wu, Ann C Brilliant, Murray H Denny, Joshua Ingram, Christie Kitchner, Terrie E Linneman, James G McGeachie, Michael J Roden, Dan M Shaffer, Christian M Shah, Anushi Weeke, Peter Weiss, Scott T Xu, Hua Medina, Marisa W Pharmacogenomics J Article Several reports have shown that statin treatment benefits patients with asthma, however inconsistent effects have been observed. The mir-152 family (148a, 148b and 152) has been implicated in asthma. These microRNAs suppress HLA-G expression, and rs1063320, a common SNP in the HLA-G 3’UTR which is associated with asthma risk, modulates miRNA binding. We report that statins up-regulate mir-148b and 152, and affect HLA-G expression in an rs1063320 dependent fashion. In addition, we found that individuals who carried the G minor allele of rs1063320 had reduced asthma related exacerbations (emergency department visits, hospitalizations or oral steroid use) compared to non-carriers (p=0.03) in statin users ascertained in the Personalized Medicine Research Project at the Marshfield Clinic (n=421). These findings support the hypothesis that rs1063320 modifies the effect of statin benefit in asthma, and thus may contribute to variation in statin efficacy for the management of this disease. 2014-09-30 2015-06 /pmc/articles/PMC4379135/ /pubmed/25266681 http://dx.doi.org/10.1038/tpj.2014.55 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Naidoo, Devesh
Wu, Ann C
Brilliant, Murray H
Denny, Joshua
Ingram, Christie
Kitchner, Terrie E
Linneman, James G
McGeachie, Michael J
Roden, Dan M
Shaffer, Christian M
Shah, Anushi
Weeke, Peter
Weiss, Scott T
Xu, Hua
Medina, Marisa W
A polymorphism in HLA-G modifies statin benefit in asthma
title A polymorphism in HLA-G modifies statin benefit in asthma
title_full A polymorphism in HLA-G modifies statin benefit in asthma
title_fullStr A polymorphism in HLA-G modifies statin benefit in asthma
title_full_unstemmed A polymorphism in HLA-G modifies statin benefit in asthma
title_short A polymorphism in HLA-G modifies statin benefit in asthma
title_sort polymorphism in hla-g modifies statin benefit in asthma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379135/
https://www.ncbi.nlm.nih.gov/pubmed/25266681
http://dx.doi.org/10.1038/tpj.2014.55
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