Cargando…

Pooled Sequencing and Rare Variant Association Tests for Identifying the Determinants of Emerging Drug Resistance in Malaria Parasites

We explored the potential of pooled sequencing to swiftly and economically identify selective sweeps due to emerging artemisinin (ART) resistance in a South-East Asian malaria parasite population. ART resistance is defined by slow parasite clearance from the blood of ART-treated patients and mutatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheeseman, Ian H., McDew-White, Marina, Phyo, Aung Pyae, Sriprawat, Kanlaya, Nosten, François, Anderson, Timothy J.C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Methods
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379400/ https://www.ncbi.nlm.nih.gov/pubmed/25534029 http://dx.doi.org/10.1093/molbev/msu397

Ejemplares similares

Population Parameters Underlying an Ongoing Soft Sweep in Southeast Asian Malaria Parasites
por: Anderson, Timothy J.C., et al.
Publicado: (2017)

Artemisinin-Resistant Plasmodium falciparum K13 Mutant Alleles, Thailand–Myanmar Border
por: Boullé, Mikael, et al.
Publicado: (2016)

Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance
por: Cerqueira, Gustavo C., et al.
Publicado: (2017)

Quantifying connectivity between local Plasmodium falciparum malaria parasite populations using identity by descent
por: Taylor, Aimee R., et al.
Publicado: (2017)

Declining Efficacy of Artemisinin Combination Therapy Against P. Falciparum Malaria on the Thai–Myanmar Border (2003–2013): The Role of Parasite Genetic Factors
por: Phyo, Aung Pyae, et al.
Publicado: (2016)

Mode and Tempo of Microsatellite Length Change in a Malaria Parasite Mutation Accumulation Experiment
por: McDew-White, Marina, et al.
Publicado: (2019)

Dihydroartemisinin-Piperaquine Versus Chloroquine in the Treatment of Plasmodium vivax Malaria in Thailand: A Randomized Controlled Trial
por: Phyo, Aung Pyae, et al.
Publicado: (2011)

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle
por: Li, Xue, et al.
Publicado: (2019)

Antigenic diversity in malaria parasites is maintained on extrachromosomal DNA
por: Ebel, Emily R., et al.
Publicado: (2023)

Poor response to artesunate treatment in two patients with severe malaria on the Thai–Myanmar border
por: Phyo, Aung Pyae, et al.
Publicado: (2018)

Genetic Evaluation of the Performance of Malaria Parasite Clearance Rate Metrics
por: Nkhoma, Standwell C., et al.
Publicado: (2013)

Single-cell genomics for dissection of complex malaria infections
por: Nair, Shalini, et al.
Publicado: (2014)

Plasmodium falciparum Kelch 13 mutations and treatment response in patients in Hpa-Pun District, Northern Kayin State, Myanmar
por: Bonnington, Craig A., et al.
Publicado: (2017)

Plasmodium falciparum rosetting protects schizonts against artemisinin
por: Lee, Wenn-Chyau, et al.
Publicado: (2021)

Malaria Burden and Artemisinin Resistance in the Mobile and Migrant Population on the Thai–Myanmar Border, 1999–2011: An Observational Study
por: Carrara, Verena I., et al.
Publicado: (2013)

Effective and cheap removal of leukocytes and platelets from Plasmodium vivax infected blood
por: Sriprawat, Kanlaya, et al.
Publicado: (2009)

Methotrexate Is Highly Potent Against Pyrimethamine-Resistant Plasmodium vivax
por: Imwong, Mallika, et al.
Publicado: (2011)

Combating multidrug‐resistant Plasmodium falciparum malaria
por: Thu, Aung Myint, et al.
Publicado: (2017)

A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development
por: Malleret, Benoît, et al.
Publicado: (2011)

Genetic architecture of transmission stage production and virulence in schistosome parasites
por: Le Clec’h, Winka, et al.
Publicado: (2021)

A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media
por: Kumar, Sudhir, et al.
Publicado: (2022)

Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria
por: Chu, Cindy S, et al.
Publicado: (2018)

Plasmodium vivax Relapse Rates Following Plasmodium falciparum Malaria Reflect Previous Transmission Intensity
por: Ashley, Elizabeth A, et al.
Publicado: (2019)

Drugs in Development for Malaria
por: Ashley, Elizabeth A., et al.
Publicado: (2018)

Close kinship within multiple-genotype malaria parasite infections
por: Nkhoma, Standwell C., et al.
Publicado: (2012)

MalariaSED: a deep learning framework to decipher the regulatory contributions of noncoding variants in malaria parasites
por: Wang, Chengqi, et al.
Publicado: (2023)

Effective detection of rare variants in pooled DNA samples using Cross-pool tailcurve analysis
por: Niranjan, Tejasvi S, et al.
Publicado: (2011)

Fitness Costs and the Rapid Spread of kelch13-C580Y Substitutions Conferring Artemisinin Resistance
por: Nair, Shalini, et al.
Publicado: (2018)

Pairwise growth competitions identify relative fitness relationships among artemisinin resistant Plasmodium falciparum field isolates
por: Tirrell, Abigail R., et al.
Publicado: (2019)

Chloroquine Versus Dihydroartemisinin-Piperaquine With Standard High-dose Primaquine Given Either for 7 Days or 14 Days in Plasmodium vivax Malaria
por: Chu, Cindy S, et al.
Publicado: (2019)

Declining Transmission and Immunity to Malaria and Emerging Artemisinin Resistance in Thailand: A Longitudinal Study
por: Ataíde, Ricardo, et al.
Publicado: (2017)

Single-cell sequencing of the small and AT-skewed genome of malaria parasites
por: Liu, Shiwei, et al.
Publicado: (2021)

High-Resolution Single-Cell Sequencing of Malaria Parasites
por: Trevino, Simon G, et al.
Publicado: (2017)

Thrombocytopaenia in pregnant women with malaria on the Thai-Burmese border
por: Tan, Saw Oo, et al.
Publicado: (2008)

Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial
por: Phyo, Aung Pyae, et al.
Publicado: (2016)

Randomized Controlled Trial of the Electrocardiographic Effects of Four Antimalarials for Pregnant Women with Uncomplicated Malaria on the Thailand-Myanmar Border
por: Saito, Makoto, et al.
Publicado: (2021)

Giemsa-Stained Wet Mount Based Method for Reticulocyte Quantification: A Viable Alternative in Resource Limited or Malaria Endemic Settings
por: Lee, Wenn-Chyau, et al.
Publicado: (2013)

Effect of High-Dose or Split-Dose Artesunate on Parasite Clearance in Artemisinin-Resistant Falciparum Malaria
por: Das, Debashish, et al.
Publicado: (2013)

Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
por: Phyo, Aung Pyae, et al.
Publicado: (2012)

Clinical impact of vivax malaria: A collection review
por: Phyo, Aung Pyae, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_0al5ol1btkhfvcusroq4b6kodn