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Structures of Eukaryotic Ribosomal Stalk Proteins and Its Complex with Trichosanthin, and Their Implications in Recruiting Ribosome-Inactivating Proteins to the Ribosomes

Ribosome-inactivating proteins (RIP) are RNA N-glycosidases that inactivate ribosomes by specifically depurinating a conserved adenine residue at the α-sarcin/ricin loop of 28S rRNA. Recent studies have pointed to the involvement of the C-terminal domain of the eukaryotic stalk proteins in facilitat...

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Detalles Bibliográficos
Autores principales: Choi, Andrew K. H., Wong, Eddie C. K., Lee, Ka-Ming, Wong, Kam-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379515/
https://www.ncbi.nlm.nih.gov/pubmed/25723321
http://dx.doi.org/10.3390/toxins7030638