Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation

BACKGROUND: The Warburg effect describes the increased reliance of tumor cells on glycolysis for ATP generation. Mitochondrial respiratory defect is thought to be an important factor leading to the Warburg effect in some types of tumor cells. Consequently, there is growing interest in developing ant...

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Detalles Bibliográficos
Autores principales: Zhou, Xiang, Chen, Ruohua, Yu, Zhenhai, Li, Rui, Li, Jiajin, Zhao, Xiaoping, Song, Shaoli, Liu, Jianjun, Huang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379549/
https://www.ncbi.nlm.nih.gov/pubmed/25888721
http://dx.doi.org/10.1186/s12943-015-0331-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379549/
https://www.ncbi.nlm.nih.gov/pubmed/25888721
http://dx.doi.org/10.1186/s12943-015-0331-3

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