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Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation
BACKGROUND: The Warburg effect describes the increased reliance of tumor cells on glycolysis for ATP generation. Mitochondrial respiratory defect is thought to be an important factor leading to the Warburg effect in some types of tumor cells. Consequently, there is growing interest in developing ant...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379549/ https://www.ncbi.nlm.nih.gov/pubmed/25888721 http://dx.doi.org/10.1186/s12943-015-0331-3 |