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DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas
BACKGROUND: Osteosarcoma is the most common malignancy of bone. HIF-1 (hypoxia-inducible factor 1) activation is critical for the metabolic reprogramming and progression of solid tumors, and DEC2 (differentiated embryonic chondrocyte gene 2) has been recently reported to suppress HIF-1 in human brea...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379712/ https://www.ncbi.nlm.nih.gov/pubmed/25884381 http://dx.doi.org/10.1186/s13046-015-0135-8 |