DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas

BACKGROUND: Osteosarcoma is the most common malignancy of bone. HIF-1 (hypoxia-inducible factor 1) activation is critical for the metabolic reprogramming and progression of solid tumors, and DEC2 (differentiated embryonic chondrocyte gene 2) has been recently reported to suppress HIF-1 in human brea...

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Detalles Bibliográficos
Autores principales: Hu, Tu, He, Nengbin, Yang, Yunsong, Yin, Chengqian, Sang, Nianli, Yang, Qingcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379712/
https://www.ncbi.nlm.nih.gov/pubmed/25884381
http://dx.doi.org/10.1186/s13046-015-0135-8

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