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Sulf1 has ligand-dependent effects on canonical and non-canonical Wnt signalling

Wnt signalling plays essential roles during embryonic development and is known to be mis-regulated in human disease. There are many molecular mechanisms that ensure tight regulation of Wnt activity. One such regulator is the heparan-sulfate-specific 6-O-endosulfatase Sulf1. Sulf1 acts extracellularl...

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Detalles Bibliográficos
Autores principales: Fellgett, Simon W., Maguire, Richard J., Pownall, Mary Elizabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379729/
https://www.ncbi.nlm.nih.gov/pubmed/25681501
http://dx.doi.org/10.1242/jcs.164467