Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme

BACKGROUND: Somatic mutations in epigenetic enzymes are frequently found in cancer tissues. The MLL3 H3K4-specific protein lysine monomethyltransferase is an important epigenetic enzyme, and it is among the most recurrently mutated enzymes in cancers. MLL3 mainly introduces H3K4me1 at enhancers. RES...

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Detalles Bibliográficos
Autores principales: Weirich, Sara, Kudithipudi, Srikanth, Kycia, Ina, Jeltsch, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379744/
https://www.ncbi.nlm.nih.gov/pubmed/25829971
http://dx.doi.org/10.1186/s13148-015-0075-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379744/
https://www.ncbi.nlm.nih.gov/pubmed/25829971
http://dx.doi.org/10.1186/s13148-015-0075-3

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