Association of the interferon signature metric with serological disease manifestations but not global activity scores in multiple cohorts of patients with SLE

OBJECTIVES: The interferon (IFN) signature (IS) in patients with systemic lupus erythematosus (SLE) includes over 100 genes induced by type I IFN pathway activation. We developed a method to quantify the IS using three genes—the IS metric (ISM)—and characterised the clinical characteristics of patie...

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Detalles Bibliográficos
Autores principales: Kennedy, William P, Maciuca, Romeo, Wolslegel, Kristen, Tew, Wei, Abbas, Alexander R, Chaivorapol, Christina, Morimoto, Alyssa, McBride, Jacqueline M, Brunetta, Paul, Richardson, Bruce C, Davis, John C, Behrens, Timothy W, Townsend, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Biomarker Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379884/
https://www.ncbi.nlm.nih.gov/pubmed/25861459
http://dx.doi.org/10.1136/lupus-2014-000080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379884/
https://www.ncbi.nlm.nih.gov/pubmed/25861459
http://dx.doi.org/10.1136/lupus-2014-000080

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