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Substrate Controlled Divergence in Polyketide Synthase Catalysis

[Image: see text] Biochemical characterization of polyketide synthases (PKSs) has relied on synthetic substrates functionalized as electrophilic esters to acylate the enzyme and initiate the catalytic cycle. In these efforts, N-acetylcysteamine thioesters have typically been employed for in vitro st...

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Detalles Bibliográficos
Autores principales: Hansen, Douglas A., Koch, Aaron A., Sherman, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379966/
https://www.ncbi.nlm.nih.gov/pubmed/25730816
http://dx.doi.org/10.1021/ja511743n