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Substrate Controlled Divergence in Polyketide Synthase Catalysis
[Image: see text] Biochemical characterization of polyketide synthases (PKSs) has relied on synthetic substrates functionalized as electrophilic esters to acylate the enzyme and initiate the catalytic cycle. In these efforts, N-acetylcysteamine thioesters have typically been employed for in vitro st...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379966/ https://www.ncbi.nlm.nih.gov/pubmed/25730816 http://dx.doi.org/10.1021/ja511743n |