Intracellular Oxidant Activity, Antioxidant Enzyme Defense System, and Cell Senescence in Fibroblasts with Trisomy 21

Down's syndrome (DS) is characterized by a complex phenotype associated with chronic oxidative stress and mitochondrial dysfunction. Overexpression of genes on chromosome-21 is thought to underlie the pathogenesis of the major phenotypic features of DS, such as premature aging. Using cultured f...

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Detalles Bibliográficos
Autores principales: Rodríguez-Sureda, Víctor, Vilches, Ángel, Sánchez, Olga, Audí, Laura, Domínguez, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380103/
https://www.ncbi.nlm.nih.gov/pubmed/25852816
http://dx.doi.org/10.1155/2015/509241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380103/
https://www.ncbi.nlm.nih.gov/pubmed/25852816
http://dx.doi.org/10.1155/2015/509241

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