Cargando…

Neuroprotective effects of activated protein C on intrauterine inflammation-induced neonatal white matter injury are associated with the downregulation of fibrinogen-like protein 2/fibroleukin prothrombinase and the inhibition of pro-inflammatory cytokine expression

Maternal intrauterine inflammation or infection is an important risk factor for neonatal cerebral white matter injury (WMI) and future neurological deficits. Activated protein C (APC), a natural anticoagulant, has been shown to exhibit anti-inflammatory, anti-apoptotic, profibrinolytic and cytoprote...

Descripción completa

Detalles Bibliográficos
Autores principales:	JIN, SHENG-JUAN, LIU, YAN, DENG, SHI-HUA, LIAO, LI-HONG, LIN, TU-LIAN, NING, QIN, LUO, XIAO-PING
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380123/ https://www.ncbi.nlm.nih.gov/pubmed/25777531 http://dx.doi.org/10.3892/ijmm.2015.2136

Ejemplares similares

Expression of prothrombinase/fibroleukin gene fg12 in lung impairment in a murine severe acute respiratory syndrome model
por: Wei-ming, Yan, et al.
Publicado: (2008)

Fibrinogen-Like Protein 2/Fibroleukin Induces Long-Term Allograft Survival in a Rat Model through Regulatory B Cells
por: Bézie, Séverine, et al.
Publicado: (2015)

103 Modulation of Human Basophilic Responses by a Fibroleukin-Allergen Fusion Protein
por: Dooper, Maaike, et al.
Publicado: (2012)

Increased Activity of Cell Membrane-Associated Prothrombinase, Fibrinogen-Like Protein 2, in Peripheral Blood Mononuclear Cells of B-Cell Lymphoma Patients
por: Rabizadeh, Esther, et al.
Publicado: (2014)

Intrauterine inflammation induced white matter injury protection by fibrinogen-like protein 2 deficiency in perinatal mice
por: Zhan, Di, et al.
Publicado: (2020)

Cryo-EM structure of the prothrombin-prothrombinase complex
por: Ruben, Eliza A., et al.
Publicado: (2022)

Novel Antibody against a Glutamic Acid-Rich Human Fibrinogen-Like Protein 2-Derived Peptide near Ser91 Inhibits hfgl2 Prothrombinase Activity
por: Li, Wen-Zhu, et al.
Publicado: (2014)

Construction of plasmids expressing Sars-CoV encoding proteins and their effects on transcription of hfgl2 prothrombinase
por: Wang, Hongwu, et al.
Publicado: (2009)

Leptospira Infection Interferes with the Prothrombinase Complex Assembly during Experimental Leptospirosis
por: Vieira, Monica L., et al.
Publicado: (2017)

Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex
por: Yegneswaran, Subramanian, et al.
Publicado: (2015)

Fibrinogen, Fibrinogen-like 1 and Fibrinogen-like 2 Proteins, and Their Effects
por: Sulimai, Nurul H., et al.
Publicado: (2022)

Molecular and Functional Analysis of the Human Prothrombinase Gene (HFGL2) and Its Role in Viral Hepatitis
por: Levy, Gary A., et al.
Publicado: (2000)

Murine lymphoid procoagulant activity induced by bacterial lipopolysaccharide and immune complexes is a monocyte prothrombinase
por: Schwartz, BS, et al.
Publicado: (1982)

Procoagulant Adaptation of a Blood Coagulation Prothrombinase-like Enzyme Complex in Australian Elapid Venom
por: Bos, Mettine H.A., et al.
Publicado: (2010)

Spellbinding Effects of the Acidic COOH-Terminus of Factor Va Heavy Chain on Prothrombinase Activity and Function
por: Hirbawi, Jamila, et al.
Publicado: (2017)

Blood coagulation factor Va's key interactive residues and regions for prothrombinase assembly and prothrombin binding
por: Schreuder, Mark, et al.
Publicado: (2019)

White matter integrity and pro-inflammatory cytokines as predictors of antidepressant response in MDD
por: Breit, S., et al.
Publicado: (2022)

White Matter and Neuroprotection in Alzheimer’s Dementia
por: Lorenzini, Luca, et al.
Publicado: (2020)

Neuroprotection and neuroregeneration: roles for the white matter
por: Baldassarro, Vito Antonio, et al.
Publicado: (2022)

White Matter Alterations Associated with Pro-inflammatory Cytokines in Patients with Major Depressive Disorder
por: Lim, Jaehwa, et al.
Publicado: (2021)

Contribution of Amino Acid Region 334−335 from Factor Va Heavy Chain to the Catalytic Efficiency of Prothrombinase
por: Barhoover, Melissa A., et al.
Publicado: (2008)

Fibrinogen-to-Albumin Ratio in Neonatal Sepsis
por: Dong, Geng, et al.
Publicado: (2023)

The downregulation of fibrinogen-like protein 1 inhibits the proliferation of lung adenocarcinoma via regulating MYC-target genes
por: Tang, Xi-Yang, et al.
Publicado: (2022)

The association of antenatal D-dimer and fibrinogen with postpartum hemorrhage and intrauterine growth restriction in preeclampsia
por: Shao, Hailing, et al.
Publicado: (2021)

Fibrinogen-related proteins in ixodid ticks
por: Sterba, Jan, et al.
Publicado: (2011)

The role of Fibrinogen-like proteins in Cancer
por: Yu, Jing, et al.
Publicado: (2021)

Contribution of Amino Acid Region 659−663 of Factor Va Heavy Chain to the Activity of Factor Xa within Prothrombinase,
por: Hirbawi, Jamila, et al.
Publicado: (2010)

Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines
por: Rao, Shan-Shan, et al.
Publicado: (2018)

Cooperative Regulation of the Activity of Factor Xa within Prothrombinase by Discrete Amino Acid Regions from Factor Va Heavy Chain
por: Barhoover, Melissa A., et al.
Publicado: (2008)

Role of the Acidic Hirudin-like COOH-Terminal Amino Acid Region of Factor Va Heavy Chain in the Enhanced Function of Prothrombinase‡
por: Hirbawi, Jamila, et al.
Publicado: (2008)

Prothrombinase-Induced Clotting Time to Measure Drug Concentrations of Rivaroxaban, Apixaban, and Edoxaban in Clinical Practice: A Cross-Sectional Study
por: Sathanantham, Vepusha, et al.
Publicado: (2022)

Astrocyte-Derived Proinflammatory Cytokines Induce Hypomyelination in the Periventricular White Matter in the Hypoxic Neonatal Brain
por: Deng, Yiyu, et al.
Publicado: (2014)

Fibrinogen and Antifibrinolytic Proteins: Interactions and Future Therapeutics
por: Pechlivani, Nikoletta, et al.
Publicado: (2021)

Pro-inflammatory cytokines in Turkish children with protein-energy malnutrition.
por: Dülger, Haluk, et al.
Publicado: (2002)

Heat Shock Protein 70 Expression is Increased in the Liver of Neonatal Intrauterine Growth Retardation Piglets
por: Li, Wei, et al.
Publicado: (2012)

Role of pro-inflammatory cytokines in Alzheimer's disease and neuroprotective effects of pegylated self-assembled nanoscaffolds
por: Rani, Varsha, et al.
Publicado: (2022)

Sudachinoid- and Ichangensin-Type Limonoids from Citrus junos Downregulate Pro-Inflammatory Cytokines
por: Shin, Jihun, et al.
Publicado: (2020)

Fibrinogen Replacement Therapy for Traumatic Coagulopathy: Does the Fibrinogen Source Matter?
por: Morrow, Gael B., et al.
Publicado: (2021)

Treadmill exercise promotes neuroprotection against cerebral ischemia–reperfusion injury via downregulation of pro-inflammatory mediators
por: Zhang, Ying, et al.
Publicado: (2016)

Fibrinogen‐like protein 2 in gastrointestinal stromal tumour
por: Pulkka, Olli‐Pekka, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vk7hr1s07km71ed99sckbb7j44