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Spirotetronate Polyketides as Leads in Drug Discovery

[Image: see text] The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent antitumor antibiotic properties collectively referred to as spirotetronate polyketides. These microbial metabolites are structurally distinguished by the presence of a spirotetronate motif...

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Detalles Bibliográficos
Autores principales: Lacoske, Michelle H., Theodorakis, Emmanuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380204/
https://www.ncbi.nlm.nih.gov/pubmed/25434976
http://dx.doi.org/10.1021/np500757w