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Spirotetronate Polyketides as Leads in Drug Discovery
[Image: see text] The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent antitumor antibiotic properties collectively referred to as spirotetronate polyketides. These microbial metabolites are structurally distinguished by the presence of a spirotetronate motif...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society and American
Society of Pharmacognosy
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380204/ https://www.ncbi.nlm.nih.gov/pubmed/25434976 http://dx.doi.org/10.1021/np500757w |
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author | Lacoske, Michelle H. Theodorakis, Emmanuel A. |
author_facet | Lacoske, Michelle H. Theodorakis, Emmanuel A. |
author_sort | Lacoske, Michelle H. |
collection | PubMed |
description | [Image: see text] The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent antitumor antibiotic properties collectively referred to as spirotetronate polyketides. These microbial metabolites are structurally distinguished by the presence of a spirotetronate motif embedded within a macrocyclic core. Glycosylation at the periphery of this core contributes to the structural complexity and bioactivity of this motif. The spirotetronate family displays impressive chemical structures, potent bioactivities, and significant pharmacological potential. This review groups the family members based on structural and biosynthetic considerations and summarizes synthetic and biological studies that aim to elucidate their mode of action and explore their pharmacological potential. |
format | Online Article Text |
id | pubmed-4380204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | American Chemical
Society and American
Society of Pharmacognosy |
record_format | MEDLINE/PubMed |
spelling | pubmed-43802042015-12-01 Spirotetronate Polyketides as Leads in Drug Discovery Lacoske, Michelle H. Theodorakis, Emmanuel A. J Nat Prod [Image: see text] The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent antitumor antibiotic properties collectively referred to as spirotetronate polyketides. These microbial metabolites are structurally distinguished by the presence of a spirotetronate motif embedded within a macrocyclic core. Glycosylation at the periphery of this core contributes to the structural complexity and bioactivity of this motif. The spirotetronate family displays impressive chemical structures, potent bioactivities, and significant pharmacological potential. This review groups the family members based on structural and biosynthetic considerations and summarizes synthetic and biological studies that aim to elucidate their mode of action and explore their pharmacological potential. American Chemical Society and American Society of Pharmacognosy 2014-12-01 2015-03-27 /pmc/articles/PMC4380204/ /pubmed/25434976 http://dx.doi.org/10.1021/np500757w Text en Copyright © 2014 American Chemical Society and American Society of Pharmacognosy This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Lacoske, Michelle H. Theodorakis, Emmanuel A. Spirotetronate Polyketides as Leads in Drug Discovery |
title | Spirotetronate Polyketides as Leads in Drug Discovery |
title_full | Spirotetronate Polyketides as Leads in Drug Discovery |
title_fullStr | Spirotetronate Polyketides as Leads in Drug Discovery |
title_full_unstemmed | Spirotetronate Polyketides as Leads in Drug Discovery |
title_short | Spirotetronate Polyketides as Leads in Drug Discovery |
title_sort | spirotetronate polyketides as leads in drug discovery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380204/ https://www.ncbi.nlm.nih.gov/pubmed/25434976 http://dx.doi.org/10.1021/np500757w |
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