APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

Binding of insulin receptor substrate proteins 1 and 2 (IRS1/2) to the insulin receptor (IR) is essential for the regulation of insulin sensitivity and energy homeostasis. However, the mechanism of IRS1/2 recruitment to the IR remains elusive. Here, we identify adaptor protein APPL1 as a critical mo...

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Detalles Bibliográficos
Autores principales: Ryu, Jiyoon, Galan, Amanda K., Xin, Xiaoban, Dong, Feng, Abdul-Ghani, Muhammad A., Zhou, Lijun, Wang, Changhua, Li, Cuiling, Holmes, Bekke M., Sloane, Lauren B., Austad, Steven N., Guo, Shaodong, Musi, Nicolas, DeFronzo, Ralph A., Deng, Chuxia, White, Morris F., Liu, Feng, Dong, Lily Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380268/
https://www.ncbi.nlm.nih.gov/pubmed/24813896
http://dx.doi.org/10.1016/j.celrep.2014.04.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380268/
https://www.ncbi.nlm.nih.gov/pubmed/24813896
http://dx.doi.org/10.1016/j.celrep.2014.04.006

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