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DNA Polymerase ζ-Dependent Lesion Bypass in Saccharomyces cerevisiae Is Accompanied by Error-Prone Copying of Long Stretches of Adjacent DNA

Translesion synthesis (TLS) helps cells to accomplish chromosomal replication in the presence of unrepaired DNA lesions. In eukaryotes, the bypass of most lesions involves a nucleotide insertion opposite the lesion by either a replicative or a specialized DNA polymerase, followed by extension of the...

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Detalles Bibliográficos
Autores principales: Kochenova, Olga V., Daee, Danielle L., Mertz, Tony M., Shcherbakova, Polina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380420/
https://www.ncbi.nlm.nih.gov/pubmed/25826305
http://dx.doi.org/10.1371/journal.pgen.1005110