Cargando…
Retinoic Acid Can Exacerbate T Cell Intrinsic TLR2 Activation to Promote Tolerance
The contribution of vitamin A to immune health has been well established. However, recent evidence indicates that its active metabolite, retinoic acid (RA), has the ability to promote both tolerogenic and inflammatory responses. While the outcome of RA-mediated immunity is dependent upon the immunol...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380421/ https://www.ncbi.nlm.nih.gov/pubmed/25826367 http://dx.doi.org/10.1371/journal.pone.0118875 |
_version_ | 1782364334046838784 |
---|---|
author | Nguyen, Vivien Pearson, Kandyce Kim, Jee-Hyun Kamdar, Karishma DePaolo, R. William |
author_facet | Nguyen, Vivien Pearson, Kandyce Kim, Jee-Hyun Kamdar, Karishma DePaolo, R. William |
author_sort | Nguyen, Vivien |
collection | PubMed |
description | The contribution of vitamin A to immune health has been well established. However, recent evidence indicates that its active metabolite, retinoic acid (RA), has the ability to promote both tolerogenic and inflammatory responses. While the outcome of RA-mediated immunity is dependent upon the immunological status of the tissue, the contribution of specific innate signals influencing this response have yet to be delineated. Here, we found that treatment with RA can dampen inflammation during intestinal injury. Importantly, we report a novel and unexpected requirement for TLR2 in RA-mediated suppression. Our data demonstrate that RA treatment enhances TLR2-dependent IL-10 production from T cells and this, in turn, potentiates T regulatory cell (T(REG)) generation without the need for activation of antigen presenting cells. These data also suggest that combinatorial therapy using RA and TLR2 ligands may be advantageous in the design of therapies to treat autoimmune or inflammatory disease. |
format | Online Article Text |
id | pubmed-4380421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43804212015-04-09 Retinoic Acid Can Exacerbate T Cell Intrinsic TLR2 Activation to Promote Tolerance Nguyen, Vivien Pearson, Kandyce Kim, Jee-Hyun Kamdar, Karishma DePaolo, R. William PLoS One Research Article The contribution of vitamin A to immune health has been well established. However, recent evidence indicates that its active metabolite, retinoic acid (RA), has the ability to promote both tolerogenic and inflammatory responses. While the outcome of RA-mediated immunity is dependent upon the immunological status of the tissue, the contribution of specific innate signals influencing this response have yet to be delineated. Here, we found that treatment with RA can dampen inflammation during intestinal injury. Importantly, we report a novel and unexpected requirement for TLR2 in RA-mediated suppression. Our data demonstrate that RA treatment enhances TLR2-dependent IL-10 production from T cells and this, in turn, potentiates T regulatory cell (T(REG)) generation without the need for activation of antigen presenting cells. These data also suggest that combinatorial therapy using RA and TLR2 ligands may be advantageous in the design of therapies to treat autoimmune or inflammatory disease. Public Library of Science 2015-03-31 /pmc/articles/PMC4380421/ /pubmed/25826367 http://dx.doi.org/10.1371/journal.pone.0118875 Text en © 2015 Nguyen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Nguyen, Vivien Pearson, Kandyce Kim, Jee-Hyun Kamdar, Karishma DePaolo, R. William Retinoic Acid Can Exacerbate T Cell Intrinsic TLR2 Activation to Promote Tolerance |
title | Retinoic Acid Can Exacerbate T Cell Intrinsic TLR2 Activation to Promote Tolerance |
title_full | Retinoic Acid Can Exacerbate T Cell Intrinsic TLR2 Activation to Promote Tolerance |
title_fullStr | Retinoic Acid Can Exacerbate T Cell Intrinsic TLR2 Activation to Promote Tolerance |
title_full_unstemmed | Retinoic Acid Can Exacerbate T Cell Intrinsic TLR2 Activation to Promote Tolerance |
title_short | Retinoic Acid Can Exacerbate T Cell Intrinsic TLR2 Activation to Promote Tolerance |
title_sort | retinoic acid can exacerbate t cell intrinsic tlr2 activation to promote tolerance |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380421/ https://www.ncbi.nlm.nih.gov/pubmed/25826367 http://dx.doi.org/10.1371/journal.pone.0118875 |
work_keys_str_mv | AT nguyenvivien retinoicacidcanexacerbatetcellintrinsictlr2activationtopromotetolerance AT pearsonkandyce retinoicacidcanexacerbatetcellintrinsictlr2activationtopromotetolerance AT kimjeehyun retinoicacidcanexacerbatetcellintrinsictlr2activationtopromotetolerance AT kamdarkarishma retinoicacidcanexacerbatetcellintrinsictlr2activationtopromotetolerance AT depaolorwilliam retinoicacidcanexacerbatetcellintrinsictlr2activationtopromotetolerance |