Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions(1,2) (www.T1DBase.org) revealing major pathways contributing to risk(3), with some loci shared across immune disorders(4–6). In order to make genetic comparisons across autoimmune disorders as informative as possible...

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Detalles Bibliográficos
Autores principales: Onengut-Gumuscu, Suna, Chen, Wei-Min, Burren, Oliver, Cooper, Nick J., Quinlan, Aaron R., Mychaleckyj, Josyf C., Farber, Emily, Bonnie, Jessica K., Szpak, Michal, Schofield, Ellen, Achuthan, Premanand, Guo, Hui, Fortune, Mary D., Stevens, Helen, Walker, Neil M., Ward, Luke D., Kundaje, Anshul, Kellis, Manolis, Daly, Mark J., Barrett, Jeffrey C., Cooper, Jason D., Deloukas, Panos, Todd, John A., Wallace, Chris, Concannon, Patrick, Rich, Stephen S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380767/
https://www.ncbi.nlm.nih.gov/pubmed/25751624
http://dx.doi.org/10.1038/ng.3245

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380767/
https://www.ncbi.nlm.nih.gov/pubmed/25751624
http://dx.doi.org/10.1038/ng.3245

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