Cargando…

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions(1,2) (www.T1DBase.org) revealing major pathways contributing to risk(3), with some loci shared across immune disorders(4–6). In order to make genetic comparisons across autoimmune disorders as informative as possible...

Descripción completa

Detalles Bibliográficos
Autores principales:	Onengut-Gumuscu, Suna, Chen, Wei-Min, Burren, Oliver, Cooper, Nick J., Quinlan, Aaron R., Mychaleckyj, Josyf C., Farber, Emily, Bonnie, Jessica K., Szpak, Michal, Schofield, Ellen, Achuthan, Premanand, Guo, Hui, Fortune, Mary D., Stevens, Helen, Walker, Neil M., Ward, Luke D., Kundaje, Anshul, Kellis, Manolis, Daly, Mark J., Barrett, Jeffrey C., Cooper, Jason D., Deloukas, Panos, Todd, John A., Wallace, Chris, Concannon, Patrick, Rich, Stephen S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380767/ https://www.ncbi.nlm.nih.gov/pubmed/25751624 http://dx.doi.org/10.1038/ng.3245

Ejemplares similares

Evidence for two independent associations with type 1 diabetes at the 12q13 locus
por: Keene, Keith L., et al.
Publicado: (2011)

TXNIP DNA methylation is associated with glycemic control over 28 years in type 1 diabetes: findings from the Pittsburgh Epidemiology of Diabetes Complications (EDC) study
por: Miller, Rachel G, et al.
Publicado: (2023)

Fine Mapping and Functional Studies of Risk Variants for Type 1 Diabetes at Chromosome 16p13.13
por: Tomlinson, M. Joseph, et al.
Publicado: (2014)

DNA methylation and 28-year cardiovascular disease risk in type 1 diabetes: the Epidemiology of Diabetes Complications (EDC) cohort study
por: Miller, Rachel G., et al.
Publicado: (2023)

A Method for Gene-Based Pathway Analysis Using Genomewide Association Study Summary Statistics Reveals Nine New Type 1 Diabetes Associations
por: Evangelou, Marina, et al.
Publicado: (2014)

Targeted Deep Sequencing in Multiple-Affected Sibships of European Ancestry Identifies Rare Deleterious Variants in PTPN22 That Confer Risk for Type 1 Diabetes
por: Ge, Yan, et al.
Publicado: (2016)

Statistical Colocalization of Genetic Risk Variants for Related Autoimmune Diseases in the Context of Common Controls
por: Fortune, Mary D., et al.
Publicado: (2015)

Leveraging type 1 diabetes human genetic and genomic data in the T1D Knowledge Portal
por: Kudtarkar, Parul, et al.
Publicado: (2023)

Leveraging type 1 diabetes human genetic and genomic data in the T1D knowledge portal
por: Kudtarkar, Parul, et al.
Publicado: (2023)

Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions
por: Mychaleckyj, Josyf C., et al.
Publicado: (2017)

Detection and correction of artefacts in estimation of rare copy number variants and analysis of rare deletions in type 1 diabetes
por: Cooper, Nicholas J., et al.
Publicado: (2015)

Imputing Amino Acid Polymorphisms in Human Leukocyte Antigens
por: Jia, Xiaoming, et al.
Publicado: (2013)

Dynamic changes in immune gene co-expression networks predict development of type 1 diabetes
por: Brænne, Ingrid, et al.
Publicado: (2021)

Precision Medicine in Type 1 Diabetes
por: Michalek, Dominika A., et al.
Publicado: (2023)

Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains
por: Wang, Qian, et al.
Publicado: (2015)

Disease-specific biases in alternative splicing and tissue-specific dysregulation revealed by multitissue profiling of lymphocyte gene expression in type 1 diabetes
por: Newman, Jeremy R.B., et al.
Publicado: (2017)

T1DBase: update 2011, organization and presentation of large-scale data sets for type 1 diabetes research
por: Burren, Oliver S., et al.
Publicado: (2011)

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples
por: Pontikos, Nikolas, et al.
Publicado: (2014)

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease
por: Gjoneska, Elizabeta, et al.
Publicado: (2015)

Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes
por: Newman, Jeremy R. B., et al.
Publicado: (2023)

Cyclic Nucleotide–Gated Channels Colocalize with Adenylyl Cyclase in Regions of Restricted Camp Diffusion
por: Rich, Thomas C., et al.
Publicado: (2000)

Coloc-stats: a unified web interface to perform colocalization analysis of genomic features
por: Simovski, Boris, et al.
Publicado: (2018)

Microbiota alteration is associated with the development of stress-induced despair behavior
por: Marin, Ioana A., et al.
Publicado: (2017)

ColocQuiaL: a QTL-GWAS colocalization pipeline
por: Chen, Brian Y, et al.
Publicado: (2022)

Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA
por: Wojcik, Genevieve L., et al.
Publicado: (2020)

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping
por: Wallace, Chris, et al.
Publicado: (2015)

Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases
por: Guo, Hui, et al.
Publicado: (2015)

CHiCP: a web-based tool for the integrative and interactive visualization of promoter capture Hi-C datasets
por: Schofield, E. C., et al.
Publicado: (2016)

Gene Expression Differences in Skin Fibroblasts in Identical Twins Discordant for Type 1 Diabetes
por: Caramori, M. Luiza, et al.
Publicado: (2012)

Genome-Wide Association Study Reveals Genetic Link between Diarrhea-Associated Entamoeba histolytica Infection and Inflammatory Bowel Disease
por: Wojcik, Genevieve L., et al.
Publicado: (2018)

EzColocalization: An ImageJ plugin for visualizing and measuring colocalization in cells and organisms
por: Stauffer, Weston, et al.
Publicado: (2018)

A Human Type 1 Diabetes Susceptibility Locus Maps to Chromosome 21q22.3
por: Concannon, Patrick, et al.
Publicado: (2008)

Genetic analysis of the GLUT10 glucose transporter (SLC2A10) polymorphisms in Caucasian American type 2 diabetes
por: Bento, Jennifer L, et al.
Publicado: (2005)

Buffy coat specimens remain viable as a DNA source for highly multiplexed genome-wide genetic tests after long term storage
por: Mychaleckyj, Josyf C, et al.
Publicado: (2011)

Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes
por: Wallace, Chris, et al.
Publicado: (2012)

epiCOLOC: Integrating Large-Scale and Context-Dependent Epigenomics Features for Comprehensive Colocalization Analysis
por: Zhou, Yao, et al.
Publicado: (2020)

Family-Based Association Analysis Confirms the Role of the Chromosome 9q21.32 Locus in the Susceptibility of Diabetic Nephropathy
por: Pezzolesi, Marcus G., et al.
Publicado: (2013)

A Genome-Wide Assessment of the Role of Untagged Copy Number Variants in Type 1 Diabetes
por: Zanda, Manuela, et al.
Publicado: (2014)

Significant linkage at chromosome 19q for otitis media with effusion and/or recurrent otitis media (COME/ROM)
por: Chen, Wei-Min, et al.
Publicado: (2011)

Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation
por: Wang, T. Tiffany, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mfev650p38joii9k30u7b34hgu