Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis, and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induc...

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Detalles Bibliográficos
Autores principales: Mo, Jung-Soon, Meng, Zhipeng, Kim, Young Chul, Park, Hyun Woo, Hansen, Carsten Gram, Kim, Soohyun, Lim, Dae-Sik, Guan, Kun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380774/
https://www.ncbi.nlm.nih.gov/pubmed/25751140
http://dx.doi.org/10.1038/ncb3111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380774/
https://www.ncbi.nlm.nih.gov/pubmed/25751140
http://dx.doi.org/10.1038/ncb3111

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