Systematic analysis of BRAF(V)(600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

Drugs that inhibit RAF/MEK signaling, such as vemurafenib, elicit profound but often temporary anti-tumor responses in patients with BRAF(V)(600E) melanoma. Adaptive responses to RAF/MEK inhibition occur on a timescale of hours to days, involve homeostatic responses that reactivate MAP kinase signal...

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Detalles Bibliográficos
Autores principales: Fallahi-Sichani, Mohammad, Moerke, Nathan J, Niepel, Mario, Zhang, Tinghu, Gray, Nathanael S, Sorger, Peter K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380931/
https://www.ncbi.nlm.nih.gov/pubmed/25814555
http://dx.doi.org/10.15252/msb.20145877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380931/
https://www.ncbi.nlm.nih.gov/pubmed/25814555
http://dx.doi.org/10.15252/msb.20145877

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